6-Glycidyloxynapht-1-yl oxymethyloxirane

15

Avoid

CAS Number: 27610-48-6

About 6-Glycidyloxynapht-1-yl oxymethyloxirane

A diglycidyl ether of a hydroxynaphthalene used as a chemical intermediate, classified as a CMR substance (carcinogen, mutagen, reprotoxic). The epoxide groups and PubChem safety score of 15 reflect severe health concerns.

Detailed Analysis

6-Glycidyloxynaphth-1-yl Oxymethyloxirane is a bis-epoxide compound derived from a hydroxynaphthalene. The presence of two epoxide groups (oxirane rings) and the naphthalene scaffold creates a compound with high reactivity and potential for DNA binding. Epoxides are well-known carcinogens and mutagens due to their electrophilic reactivity with nucleic acids and proteins. The PubChem safety score of 15 confirms this compound is considered highly hazardous. Under EU cosmetics regulation, substances classified as CMR Category 1A or 1B are generally prohibited in cosmetic products.

Known Concerns

  • ⚠ CMR substance - carcinogenicity, mutagenicity, and reprotoxicity concerns
  • ⚠ Highly reactive epoxide groups can bind to DNA
  • ⚠ Skin sensitizer (H315, H317)
  • ⚠ Acute dermal toxicity (H312)
  • ⚠ Suspected of causing genetic defects (H341)
  • ⚠ Very hazardous to aquatic life (H412)

Safety Score

15

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.