T-BUTYL ALCOHOL

Other

45

Caution

CAS Number: 75-65-0

About T-BUTYL ALCOHOL

T-Butyl Alcohol is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Detailed Analysis

tert-Butyl Alcohol (2-methyl-2-propanol, CAS 75-65-0, PubChem CID 6386) is a tertiary alcohol used as a solvent and denaturant in cosmetics. It is classified as flammable (GHS H225) and carries concerns for reproductive/developmental toxicity per California Prop 65 and some regulatory bodies. The NTP conducted a 2-year carcinogenicity study in rodents showing kidney tumors in male rats (species-specific mechanism) and thyroid tumors in mice. While the CIR Expert Panel found it safe as used in cosmetics at low concentrations, it remains controversial due to its systemic toxicity profile. It is a human xenobiotic metabolite of MTBE.

Known Concerns

  • ⚠ Reproductive/developmental toxicity concerns (Prop 65 listed)
  • ⚠ CNS depressant at high concentrations
  • ⚠ Flammable — safety handling concerns
  • ⚠ Rodent carcinogenicity data (species-specific but notable)
  • ⚠ Potential for inhalation toxicity

Safety Score

45

Caution

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.