KETOGLUTARIC ACID
Fragrance
Good
CAS Number: 328-50-7
About KETOGLUTARIC ACID
Alpha-ketoglutaric acid — a naturally occurring metabolite that boosts collagen production and reduces wrinkles. Shows promise as an anti-aging ingredient but can irritate sensitive or damaged skin.
Detailed Analysis
Ketoglutaric Acid (alpha-ketoglutaric acid, C₅H₆O₅, CAS 328-50-7) is an organic acid and key metabolite in the Krebs cycle. In cosmetics, it functions as a deodorant per CosIng and as an anti-wrinkle active. Studies show topical 1% AKG significantly reduces wrinkles by stimulating procollagen synthesis in dermal fibroblasts and enhancing prolidase activity. Also acts as a natural moisturizing factor and cellular antioxidant. Considered possibly safe topically for up to 8 weeks. Can cause skin inflammation and serious eye damage — avoid on compromised skin.
What It Does
Skin Benefits
- ✓ Stimulates collagen production and reduces wrinkles
- ✓ Natural moisturizing factor
- ✓ Cellular antioxidant — neutralizes free radicals
- ✓ Improves skin hydration and firmness
- ✓ Wound healing support
Known Concerns
- ⚠ Can cause skin inflammation on damaged or abraded skin
- ⚠ Causes serious eye damage — classified as eye irritant
- ⚠ Respiratory irritant in pure form
- ⚠ Should not be applied to open wounds or cuts
Safety Score
Good
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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Download LuxSenseThis information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.