KALANCHOE GASTONIS-BONNIERI LEAF EXTRACT

Antioxidant

42

Caution

About KALANCHOE GASTONIS-BONNIERI LEAF EXTRACT

A succulent plant extract containing bufadienolide cardiac glycosides that can be absorbed through skin and cause systemic toxicity, with documented cardiotoxic effects in humans and animals.

Detailed Analysis

Kalanchoe gastonis-bonnieri (Crassulaceae) is documented to contain bufadienolide-type cardiac glycosides including bersaldegenin-3-acetate and glaucridoside. These compounds inhibit Na+/K+-ATPase, causing dose-dependent cardiotoxicity including bradycardia and arrhythmias. The European Medicines Agency has flagged Kalanchoe species as containing potentially toxic bufadienolides. The Cosmetics Regulation (EC) No 1223/2009 does not specifically list Kalanchoe gastonis-bonnieri in its annexes; however, the documented systemic toxicity risk, particularly for damaged skin, breastfeeding women, children, and elderly, warrants significant caution.

What It Does

ANTIOXIDANT SKIN CONDITIONING - EMOLLIENT SKIN CONDITIONING

Skin Benefits

  • ✓ Antioxidant flavonoids in the extract provide some free radical scavenging activity
  • ✓ Traditional wound healing use documented in ethnobotany

Known Concerns

  • ⚠ Contains bufadienolide cardiac glycosides with documented cardiotoxic potential; EU EMA has flagged Kalanchoe species as containing potentially toxic compounds
  • ⚠ Skin absorption of bufadienolides is possible, particularly through compromised skin or with long-term leave-on use
  • ⚠ Specific concern for pregnant/breastfeeding individuals, children, elderly, and those with cardiac conditions
  • ⚠ Not listed in EU CosIng Annexes but toxicity profile warrants cautionary use or avoidance

Safety Score

42

Caution

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.