JAPANESE PUFFERFISH SKIN EXTRACT
Other
Avoid
About JAPANESE PUFFERFISH SKIN EXTRACT
Japanese pufferfish skin extract is a prohibited material under EU Annex II entry 419 due to tetrodotoxin content from animal byproduct regulations.
Detailed Analysis
Japanese pufferfish (Takifugu rubripes or related species) skin contains tetrodotoxin (TTX), one of the most potent neurotoxins known, which blocks sodium channels causing respiratory paralysis and death. EU Regulation 1223/2009 Annex II entry 419 specifically references that Category 1 and Category 2 materials as defined in Regulation (EC) No 1069/2009 (animal by-products) are prohibited in cosmetic products. Pufferfish-derived material falls under these categories due to the inherent toxicity of tetrodotoxin. There is no safe level of topical application for this highly toxic neurotoxin. The restriction notice in the input data correctly identifies the regulatory barrier.
What It Does
Known Concerns
- ⚠ EU Annex II entry 419 PROHIBITED - animal by-product from Category 1/2 materials
- ⚠ Contains tetrodotoxin (TTX) - highly potent neurotoxin blocking sodium channels
- ⚠ No safe cosmetic use established - absolute prohibition in EU
Safety Score
Avoid
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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Download LuxSenseThis information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.