ILOMASTAT
Other
Caution
CAS Number: 142880-36-2
About ILOMASTAT
Ilomastat is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.
Detailed Analysis
Ilomastat (GM6001) is a broad-spectrum hydroxamate-based matrix metalloproteinase (MMP) inhibitor originally developed for pharmaceutical applications including wound healing, corneal disease, and cancer. While MMP inhibitors have theoretical anti-aging skin benefits by preventing collagen degradation, ilomastat lacks adequate safety data for cosmetic topical use. It is not listed in CosIng and would require extensive safety evaluation before cosmetic formulation. Systemic MMP inhibition raises concerns about interference with normal tissue remodeling.
Skin Benefits
- ✓ Theoretical anti-aging via MMP inhibition
- ✓ May support collagen preservation
Known Concerns
- ⚠ Not listed in CosIng — lacks EU cosmetic approval
- ⚠ Insufficient topical safety data
- ⚠ Broad MMP inhibition may interfere with normal skin remodeling
- ⚠ Developed as a pharmaceutical agent — requires prescription-level evaluation
Safety Score
Caution
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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