DAIDZEIN
Other
Moderate
CAS Number: 486-66-8
About DAIDZEIN
Daidzein is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.
Detailed Analysis
Daidzein (CAS 486-66-8) is a naturally occurring isoflavone phytoestrogen present in soybeans and other legumes. Under EU Regulation 1223/2009, it is listed in Annex III (entry III/374) with restriction conditions for cosmetic use. As a hormonal-active compound, it raises concerns about endocrine disruption, particularly with long-term use or application on damaged skin, limiting its overall safety score despite antioxidant benefits.
Skin Benefits
- ✓ Antioxidant protection against oxidative stress
- ✓ Phytoestrogenic activity may support mature skin
- ✓ Potential anti-aging benefits via collagen stimulation
Known Concerns
- ⚠ EU Annex III restricted — III/374 applies
- ⚠ Phytoestrogenic activity raises endocrine disruption concerns
- ⚠ May enhance absorption through compromised skin barriers
Safety Score
Moderate
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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