6-Methoxy-m-toluidine (p-Cresidine)
Other
Avoid
CAS Number: 120-71-8
About 6-Methoxy-m-toluidine (p-Cresidine)
A known carcinogen with H350 classification (may cause cancer), making it banned in EU cosmetics under Annex II regardless of concentration or application type.
Detailed Analysis
p-Cresidine (6-methoxy-m-toluidine) is classified as H350 (may cause cancer) and H302 (harmful if swallowed), with additional concerns around H319 (eye irritation), H315 (skin irritation), H351 (suspected carcinogen), and H371 (organ systemic effects). It is classified as a Category 2 carcinogen by IARC and is listed in EU Regulation 1223/2009 Annex II — the list of substances absolutely prohibited in cosmetic products. The methoxy-substituted aromatic amine structure is associated with bladder carcinogenicity in occupational studies. No safe concentration exists that would permit its use in cosmetics; it is banned regardless of the type of cosmetic product or rinse-off versus leave-on application. The compound has no legitimate cosmetic application and is exclusively an industrial chemical intermediate.
Known Concerns
- ⚠ Banned in EU cosmetics — Annex II
- ⚠ Known carcinogen (IARC Category 2, H350)
- ⚠ Suspected organ systemic toxicity
- ⚠ No safe cosmetic use — absolute prohibition
Safety Score
Avoid
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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