4-AMINO-3-NITROPHENOL

Other

42

Caution

CAS Number: 610-81-1

About 4-AMINO-3-NITROPHENOL

A hair dye intermediate — used to create reddish-brown shades. EU-restricted (Annex III/215) due to toxicity concerns including skin sensitization, irritation, and being harmful if swallowed.

Detailed Analysis

4-Amino-3-Nitrophenol (CAS 610-81-1) is a nitroaminophenol used as an oxidative and semi-permanent hair dye intermediate, producing reddish to brown shades. EU Annex III/215 restricts its use with specific concentration limits. GHS classifications include H302 (harmful if swallowed), H315 (skin irritant), H317 (skin sensitizer), H319 (eye irritant), and H335 (respiratory irritant). The SCCS has evaluated this ingredient multiple times and allows use only under specified conditions in oxidative and non-oxidative hair dye products. Must not be used with nitrosating agents due to potential nitrosamine formation.

What It Does

HAIR DYEING

Skin Benefits

  • ✓ None — this is a hair coloring agent, not a skin-care ingredient

Known Concerns

  • ⚠ EU Annex III restricted (III/215)
  • ⚠ Skin sensitizer (H317) — allergic contact dermatitis
  • ⚠ Harmful if swallowed (H302)
  • ⚠ Skin and eye irritant (H315, H319)
  • ⚠ Respiratory irritant (H335)
  • ⚠ Must not be mixed with nitrosating agents

Safety Score

42

Caution

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.