4,6-Dimethyl-8-tert-butylcoumarin, when used as a fragrance ingredient
Other
Moderate
CAS Number: 17874-34-9
About 4,6-Dimethyl-8-tert-butylcoumarin, when used as a fragrance ingredient
Used in cosmetic product formulation. Exercise caution due to limited available safety data.
Detailed Analysis
4,6-Dimethyl-8-tert-butylcoumarin is a 7,8-disubstituted coumarin where the tert-butyl group at position 8 provides steric hindrance that reduces photosensitising potential compared to unsubstituted coumarin. It falls under EU Annex III restrictions for coumarin-class fragrance allergens and is subject to IFRA guidelines limiting use levels in various product categories. The methyl substituents at positions 4 and 6 further modify its biological activity relative to simpler coumarins.
Known Concerns
- ⚠ Coumarin-class photosensitisation concern, reduced by tert-butyl substitution
- ⚠ EU Annex III restricted fragrance allergen
Safety Score
Moderate
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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