4,4'-Methylenedi-o-toluidine

Other

20

Avoid

CAS Number: 838-88-0

About 4,4'-Methylenedi-o-toluidine

Methylenedi-o-toluidine is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Detailed Analysis

4,4'-Methylenedi-o-toluidine (MDI-ortho-toluidine) is classified as a suspected carcinogen (H350) and shows acute aquatic toxicity (H400, H410, H411). It is not listed in EU Annex II or III but falls under general CMR substance regulation requiring authorization under EU REACH. Its structural similarity to known carcinogenic aromatic amines (including o-toluidine itself) raises significant safety concerns for any cosmetic application.

Known Concerns

  • ⚠ H350 suspected carcinogen
  • ⚠ H400/H410/H411 aquatic toxicity
  • ⚠ CMR classification concern
  • ⚠ Related to known carcinogenic aromatic amines

Safety Score

20

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.