4,4'-Bi-o-toluidine (ortho-Tolidine)

Other

2

Avoid

CAS Number: 119-93-7

About 4,4'-Bi-o-toluidine (ortho-Tolidine)

A confirmed carcinogen and suspected mutagen — banned in cosmetics. Derived from benzidine chemistry.

Detailed Analysis

ortho-Tolidine (3,3'-dimethylbenzidine) is a biphenyl aromatic diamine classified H350 (may cause cancer), H341 (suspected mutagen), and H372 (organ damage from repeated exposure). Like its parent compound benzidine, it is a confirmed bladder carcinogen. Prohibited under EU Cosmetics Regulation Annex II and REACH Annex XVII.

Known Concerns

  • ⚠ EU Annex II banned substance
  • ⚠ Confirmed carcinogen (H350)
  • ⚠ Suspected mutagen (H341)
  • ⚠ Organ toxicity from chronic exposure
  • ⚠ Benzidine derivative
  • ⚠ Toxic to aquatic life

Safety Score

2

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

🏛

EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.