4,4'-Bi-o-toluidine dihydrochloride

Other

15

Avoid

CAS Number: 612-82-8

About 4,4'-Bi-o-toluidine dihydrochloride

Bi-o-toluidine dihydrochloride is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Detailed Analysis

4,4'-Bi-o-toluidine dihydrochloride (o-tolidine dihydrochloride) is a dimeric aromatic amine classified with H350 (suspected of causing cancer) and H411 (toxic to aquatic life with long-lasting effects). The biphenyl structure combined with aromatic amine functional groups creates significant concern for carcinogenicity through similar metabolic activation pathways as other aromatic amines. EU REACH regulation requires authorization for this substance, and cosmetic use is highly restricted.

Known Concerns

  • ⚠ H350 suspected carcinogen
  • ⚠ H411 aquatic toxicity with long-lasting effects
  • ⚠ CMR classification concern
  • ⚠ Severe EU regulatory restrictions

Safety Score

15

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.