3,4-Dinitrotoluene

8

Avoid

CAS Number: 610-39-9

About 3,4-Dinitrotoluene

3,4-dinitrotoluene is a cosmetic ingredient. Exercise caution due to limited available safety data.

Detailed Analysis

Like its 2,5-isomer, 3,4-dinitrotoluene is classified as a CMR substance under EU law (H350 carcinogen, H361f reproductive toxicant, H317 skin sensitisation). The combined profile of carcinogenicity, reprotoxicity, and sensitisation makes this compound one of the most highly restricted classes under EU cosmetic regulations. The nitro group's bioactivation to reactive intermediates is the mechanistic basis for its toxicity.

Known Concerns

  • ⚠ EU Annex II CMR prohibition
  • ⚠ H350: known human carcinogen
  • ⚠ H361f: suspected reproductive toxicant
  • ⚠ H317: skin sensitisation confirmed
  • ⚠ H301/H311/H331: acute toxicity across exposure routes

Safety Score

8

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.