2,2'-Dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylmethane (Hexachlorophene (INN))

5

Avoid

CAS Number: 70-30-4

About 2,2'-Dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylmethane (Hexachlorophene (INN))

A cosmetic ingredient. Raw material has significant toxicity. Exercise caution due to limited available safety data.

Detailed Analysis

Hexachlorophene is a chlorinated bisphenolic antimicrobial preservative historically used in cosmetic and toiletry products. The EU Cosmetics Regulation (EC 1223/2009) Annex II entry 99 prohibits its use in cosmetic products due to percutaneous absorption causing neurotoxic effects (vacuolar encephalopathy), particularly in infants. It carries hazard statements H301 (acute toxicity), H311 (skin absorption), H361 (reproductive toxicity), H370/H372 (organ toxicity), and H410 (very toxic to aquatic life).

Known Concerns

  • ⚠ Banned in EU cosmetic products (Annex II)
  • ⚠ Neurotoxic (vacuolar encephalopathy)
  • ⚠ Percutaneous absorption toxicity
  • ⚠ Reproductive toxicity suspected H361
  • ⚠ Very toxic to aquatic organisms H410

Safety Score

5

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.