2,2,6-Trimethyl-4-piperidyl benzoate (eucaine) and its salts

22

Avoid

CAS Number: 500-34-5

About 2,2,6-Trimethyl-4-piperidyl benzoate (eucaine) and its salts

A local anesthetic pharmaceutical compound not approved for cosmetic use in the EU, with structural similarity to cocaine and ester-type anesthetic risks.

Detailed Analysis

Eucaine (2,2,6-trimethyl-4-piperidyl benzoate) is an ester-type local anesthetic structurally related to cocaine. Ester-type anesthetics are associated with allergic contact dermatitis and methemoglobinemia. It is not listed in EU CosIng and is not permitted in cosmetic products under Regulation 1223/2009.

Known Concerns

  • ⚠ Not approved for cosmetic use in EU
  • ⚠ Ester-type anesthetic with sensitization risk
  • ⚠ Potential for methemoglobinemia
  • ⚠ Allergic contact dermatitis risk

Safety Score

22

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.