1,1-Bis(dimethylaminomethyl)propyl benzoate (amydricaine, alypine) and its salts
Other
Caution
CAS Number: 963-07-5
About 1,1-Bis(dimethylaminomethyl)propyl benzoate (amydricaine, alypine) and its salts
A local anesthetic compound banned from cosmetic use in the EU due to its pharmaceutical status and sensitization concerns.
Detailed Analysis
Amydricaine (alyprine) is a local anesthetic of the amino ester type. It is listed in EU Annex II of Regulation EC 1223/2009, which prohibits its use in cosmetic products. Local anesthetics of the ester type (such as amydricaine) have been restricted in cosmetics for decades due to their sensitization potential and availability as pharmaceutical substances. Its presence in any cosmetic ingredient list indicates non-compliance with EU cosmetic regulation.
Known Concerns
- ⚠ EU Annex II — explicitly banned from cosmetic products
- ⚠ Local anesthetic of ester type — high sensitization risk
- ⚠ Pharmaceutical substance — not appropriate for cosmetic formulations
Safety Score
Caution
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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