Xylometazoline (INN) and its salts

18

Avoid

CAS Number: 526-36-3

About Xylometazoline (INN) and its salts

Xylometazoline (inn) And Its Salts is a cosmetic ingredient. Exercise caution due to limited available safety data.

Detailed Analysis

Xylometazoline is an alpha-adrenergic agonist used as a topical nasal decongestant. Its inclusion in EU Annex III (restricted substances) at concentrations >=0.1% reflects concerns about its sympathomimetic pharmacological activity. While permitted at lower concentrations in some cosmetic contexts, the regulatory threshold is set to prevent pharmacological effects that would classify the product differently from conventional cosmetics.

Known Concerns

  • ⚠ EU Annex III restricted at >=0.1%
  • ⚠ Pharmacologically active sympathomimetic
  • ⚠ Potential for vasoconstrictive effects

Safety Score

18

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.