KETOCONAZOLE
Avoid
CAS Number: 65277-42-1
About KETOCONAZOLE
An antifungal with endocrine disruption concerns and EU Annex II restrictions on cosmetic use.
Detailed Analysis
Ketoconazole is listed in EU Annex II/1528 as a prohibited substance for cosmetic use due to its endocrine-disrupting potential (H360F - may damage fertility). It was formerly used in anti-dandruff shampoos but has been superseded by safer alternatives. Beyond cosmetic restrictions, it is regulated as a prescription pharmaceutical. The SCCS has confirmed that ketoconazole has no place in cosmetic formulations due to its risk profile.
Known Concerns
- ⚠ EU Annex II prohibited (cosmetic ban)
- ⚠ Endocrine disruption (H360F)
- ⚠ Organ toxicity (H373)
- ⚠ Aquatic toxicity (H400/H410)
Safety Score
Avoid
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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Download LuxSenseThis information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.