IMMORTALIZED HUMAN TOOTH PULP STEM CELL CONDITIONED MEDIA
Other
Avoid
About IMMORTALIZED HUMAN TOOTH PULP STEM CELL CONDITIONED MEDIA
Growth media conditioned by immortalised human tooth pulp stem cells carrying HPV E6/E7 and hTERT genes, classified under EU cosmetic regulation Annex II/416 as a substance of particular concern due to its genetic modification and human-cell origin.
Detailed Analysis
This ingredient consists of the culture medium removed after growth of human tooth pulp stem cells that have been immortalised using HPV oncogenes (E6/E7) and telomerase reverse transcriptase (hTERT). The EU classifies materials derived from immortalised human cells, particularly those modified with viral genes, under the strictest cosmetic restrictions. The II/416 reference indicates restriction under Regulation 1223/2009 Annex II or special assessment requirements, making this a high-concern ingredient with significant safety evaluation requirements before cosmetic use.
Skin Benefits
- ✓ Growth factor and cytokine content from stem cell conditioned media may support dermal regeneration
Known Concerns
- ⚠ EU II/416 restriction: subject to stringent safety assessment
- ⚠ Contains genetically modified human cells with HPV oncogene insertions
- ⚠ Oncogenic risk from E6/E7 gene expression requires thorough safety dossier
- ⚠ Potential for xenogenic pathogen transmission from human tissue source
Safety Score
Avoid
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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